Description

Paclitaxel CAS NO 33069-62-4 is a highly potent, diterpenoid natural product and a key member of the taxane class of chemotherapeutic agents. Its primary value lies in its unique mechanism of action, which stabilizes microtubules and inhibits cell division, making it a cornerstone in oncology treatment regimens. This active pharmaceutical ingredient (API) is essential for pharmaceutical manufacturers, research institutions, and compounding pharmacies developing and producing injectable formulations for cancer therapy.

Application

• Oncology Drug Manufacturing: Primary API for the production of injectable chemotherapy drugs used to treat breast, ovarian, lung, and pancreatic cancers.
• Pharmaceutical Research & Development: Critical compound for preclinical and clinical studies investigating new cancer treatment protocols and combination therapies.
• Drug-Loaded Medical Devices: Used in the coating of stents and other implantable devices for localized, controlled drug delivery.
• Nanoparticle & Liposomal Formulations: Serves as the active payload in advanced drug delivery systems designed to improve solubility and target tumors.
• Reference Standard: High-purity grade used as a calibration standard in analytical laboratories for quality control of pharmaceutical products.
• Anticancer Mechanism Studies: Utilized in biochemical and cell biology research to study microtubule dynamics and apoptosis.

Basic Information

Product Name	Paclitaxel
CAS No.	33069-62-4
Molecular Formula	C47H51NO14
Molecular Weight	853.91 g/mol
Synonyms	Taxol; NSC 125973; BMS-181339-01; 5β,20-Epoxy-1,2α,4,7β,10β,13α-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine; Anzatax; Onxol; Abraxane (albumin-bound nanoparticle form); [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-β-(Benzoylamino)-α-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester
EINECS	251-375-8

Quality Control

Our Paclitaxel is manufactured under strict quality management systems. It undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets high-grade pharmaceutical standards. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, residual solvents, and other critical parameters is provided with each batch to support regulatory filings and ensure supply chain integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) or as specified on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% - 102.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Specific Rotation	-49° to -55° (c=1, MeOH)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.