Description

Etoposide CAS NO 33419-42-0 is a semi-synthetic derivative of podophyllotoxin, functioning as a potent topoisomerase II inhibitor. This critical pharmaceutical active ingredient is essential for its cytostatic activity, which disrupts DNA replication in rapidly dividing cells. It is a fundamental component in the formulation of injectable and oral chemotherapeutic agents, primarily targeting oncology research, clinical treatment, and pharmaceutical manufacturing.

Application

• Oncological Drug Formulation: Primary active pharmaceutical ingredient (API) in injectable solutions and oral capsules for chemotherapy.
• Treatment of Specific Cancers: Key therapeutic agent for testicular cancer, small-cell lung cancer, lymphomas, and leukemias.
• Clinical Research & Development: Used in preclinical and clinical studies for evaluating new combination therapies and treatment protocols.
• Pharmaceutical Intermediates: Serves as a crucial intermediate in the synthesis of more complex anticancer prodrugs or derivatives.
• Reference Standard: Utilized as a high-purity analytical standard in quality control laboratories for drug assay and impurity profiling.

Basic Information

Product Name	Etoposide
CAS No.	33419-42-0
Molecular Formula	C29H32O13
Molecular Weight	588.56 g/mol
Synonyms	VP-16; VP-16-213; Etoposidum; 4'-Demethylepipodophyllotoxin 9-[4,6-O-(R)-ethylidene-β-D-glucopyranoside]; (5R,5aR,8aR,9S)-9-[[4,6-O-[(R)-Ethylidene]-β-D-glucopyranosyl]oxy]-5-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8,8a,9,10-hexahydro-5H-[1,3]dioxolo[4,5-g]isoquinolino[5,4-a]isoquinoline-1,11-dione; ETOPOPHOS (phosphate ester prodrug); Vepesid; Demethyl Epipodophyllotoxin Ethylidine Glucoside
EINECS	251-493-6

Quality Control

Our Etoposide is manufactured under strict quality management systems, targeting compliance with pharmaceutical-grade standards (USP/EP). Every batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via HPLC and related substances tests. A Certificate of Analysis (COA) detailing all specifications and results is provided with each shipment to ensure full traceability and regulatory support for your applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. Due to its sensitivity, the product should be handled under an inert atmosphere to minimize oxidation. Keep the container in a dry, cool, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 5.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.