Description

Vinblastine Sulfate is a critical pharmaceutical active ingredient derived from the Madagascar periwinkle plant, Catharanthus roseus. It is a potent vinca alkaloid that functions as a microtubule destabilizing agent, making it a cornerstone chemotherapeutic agent in modern oncology. This high-purity compound is essential for the formulation of injectable cancer treatments, primarily targeting hematologic malignancies and certain solid tumors. Pharmaceutical manufacturers and research institutions globally rely on a consistent, high-quality supply of Vinblastine Sulfate CAS NO 143-67-9 for drug production and advanced clinical studies.

Application

• Oncological Drug Manufacturing: Primary active pharmaceutical ingredient (API) in injectable formulations for chemotherapy.
• Hodgkin's & Non-Hodgkin's Lymphoma Treatment: A key component in first-line combination chemotherapy regimens (e.g., ABVD).
• Testicular Cancer Therapy: Used in combination with other agents for treating germ cell tumors.
• Breast Cancer & Kaposi's Sarcoma Management: Employed in specific treatment protocols for these conditions.
• Pharmaceutical Research & Development: Serves as a reference standard and a lead compound for developing novel anti-mitotic agents.
• Biochemical Research: Used in cell biology studies to investigate microtubule dynamics, spindle formation, and cell cycle arrest.

Basic Information

Item	Detail
Product Name	Vinblastine Sulfate
CAS No.	143-67-9
Molecular Formula	C46H58N4O9 · H2SO4
Molecular Weight	909.06 g/mol
Synonyms	Vincaleukoblastine Sulfate; VLB Sulfate; Exal; Velban; Velbe; Vinblastine Sulphate; 3',4'-Didehydro-4'-deoxy-8'-norvincaleukoblastine Sulfate; NSC-49842
EINECS	205-620-3

Quality Control

Our Vinblastine Sulfate is manufactured and tested under strict quality systems to meet the exacting standards of the global pharmaceutical industry. Each batch is subjected to comprehensive analytical testing, including identity confirmation, potency assay, and impurity profiling via advanced techniques like HPLC and mass spectrometry. We provide full traceability and support regulatory submissions with comprehensive documentation. A detailed Certificate of Analysis (COA), confirming compliance with specifications, is available for every lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at a controlled room temperature, ideally between 15°C and 25°C (59°F and 77°F). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term stability, consider storage at 2°C to 8°C (36°F to 46°F).

Specification

Item	Specification
Appearance	White to slightly yellow, crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0 %
Residue on Ignition	≤ 0.5 %
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Microbial Limits	Meets requirements for non-sterile substances

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.