Description

Oxiranecarboxylic acid, 3-(((3-methyl-1-((4-((2,3,4-trimethoxyphenyl)methyl)-1-piperazinyl)carbonyl)butyl)amino)carbonyl)-, monosodium salt, (2R-(2-alpha,3-beta(S*)))- is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) requiring precise molecular architecture. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in specialized chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex, high-value active pharmaceutical ingredients (APIs).
• Chemical Research & Development: Used in medicinal chemistry for lead optimization and the creation of novel molecular entities.
• Process Chemistry: Serves as a critical chiral synthon in scalable, multi-step synthetic routes for drug candidates.
• Contract Manufacturing (CMO/CDMO): Supplied to organizations specializing in the custom synthesis of pharmaceutical compounds under cGMP.
• Academic Research: Employed in university and institutional labs for studies in organic synthesis and pharmacology.

Basic Information

Product Name	Oxiranecarboxylic acid, 3-(((3-methyl-1-((4-((2,3,4-trimethoxyphenyl)methyl)-1-piperazinyl)carbonyl)butyl)amino)carbonyl)-, monosodium salt, (2R-(2-alpha,3-beta(S*)))-
CAS No.	84518-83-2
Molecular Formula	C24H34N3O8Na
Molecular Weight	515.54 g/mol
Synonyms	Monosodium (2R,3S)-3-({[(3-Methyl-1-{[4-[(2,3,4-Trimethoxyphenyl)methyl]piperazin-1-yl]carbonyl}butyl)amino]carbonyl})oxiran-2-carboxylate; Sodium (2R,3S)-Epoxysuccinyl-Leu-Pip-Tmp; (2R,3S)-E-64-c monosodium salt; Protease Inhibitor Intermediate; E-64 derivative sodium salt; (2R,3S)-3-((N-((S)-1-((4-((2,3,4-Trimethoxybenzyl)piperazin-1-yl))-3-methyl-1-oxobutan-2-yl)carbamoyl)oxirane-2-carboxylic acid sodium salt
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure compliance with rigorous standards suitable for pharmaceutical R&D. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.