Description

(R)-TRIP, (11bR)-4-Hydroxy-2,6-bis[2,4,6-tris(1-methylethyl)phenyl]dinaphtho[2,1-d:1',2'-f]-1,3,2-dioxaphosphepin 4-oxide is a sophisticated, chiral monophosphoric acid derivative, widely recognized as a highly effective Brønsted acid catalyst. Its core value lies in enabling precise and efficient enantioselective transformations, which are critical for synthesizing high-value chiral intermediates and active pharmaceutical ingredients (APIs). This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-performance catalysts for asymmetric synthesis.

Application

• Asymmetric Organocatalysis: Serves as a powerful chiral Brønsted acid catalyst for a wide range of enantioselective reactions.
• Pharmaceutical Intermediate Synthesis: Critical for the production of enantiomerically pure drug candidates and APIs, including those for central nervous system (CNS) and cardiovascular therapies.
• Fine Chemical Manufacturing: Used in the synthesis of complex, chiral molecules for fragrances, flavors, and advanced materials.
• Agrochemical Research: Facilitates the development of enantiomerically pure pesticides and herbicides with improved efficacy and environmental profiles.
• Academic & Process R&D: A valuable tool for methodology development and scaling up novel asymmetric catalytic processes.
• Chiral Resolution & Analysis: Can be employed in the development of chiral stationary phases or as a chiral selector in analytical methods.

Basic Information

Product Name	(R)-TRIP
CAS No.	791616-63-2
Molecular Formula	C54H61O4P
Molecular Weight	829.03 g/mol
Synonyms	(R)-3,3'-Bis(2,4,6-triisopropylphenyl)-1,1'-bi-2-naphthol cyclic monophosphate; (R)-TRIP Phosphoric Acid; (R)-TRIP PA; (R)-TRIP Acid; (R)-TRIP Catalyst; (11bR)-4-Hydroxy-2,6-bis(2,4,6-triisopropylphenyl)dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin 4-oxide; (R)-VAPOL Phosphoric Acid Derivative; Chiral Phosphoric Acid TRIP
EINECS	Contact for details

Quality Control

Our (R)-TRIP is manufactured under strict quality management systems to ensure batch-to-batch consistency and high catalytic performance. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to meet the exacting standards required for asymmetric synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain optimal stability and catalytic activity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.