Description

(R,R)-(-)-6,6'-[(1,1'-Biphenyl-2,2'-diyl)]bis[4,8-di-t-butyl-1,2,10,11-tetramethyl]dibenzo[d,f][1,3,2]dioxaphosphepin,bisacetonitrileadduct,min.95%(R,R)-Kelliphite is a high-purity, chiral phosphine ligand widely recognized for its exceptional performance in asymmetric catalysis. Its value lies in providing superior enantioselectivity and catalytic activity in critical synthetic transformations, enabling the production of high-value, optically pure intermediates. This product is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable and efficient chiral auxiliaries.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical API synthesis.
• Asymmetric Cross-Coupling Reactions: Facilitates C-C and C-X bond-forming reactions with high stereocontrol, crucial for constructing complex chiral molecules.
• Chiral Catalyst Preparation: Serves as a precursor or direct ligand in the synthesis of transition metal catalysts (e.g., Rh, Ru, Pd complexes) for asymmetric synthesis.
• Fine Chemical and Agrochemical Intermediate Synthesis: Enables the production of enantiomerically pure intermediates for advanced crop protection agents and specialty chemicals.
• Academic and Industrial R&D: Used in method development and discovery chemistry for exploring new asymmetric catalytic processes.
• Process Chemistry Optimization: Employed to improve the yield, selectivity, and cost-efficiency of scaled-up manufacturing routes for chiral compounds.

Basic Information

Product Name	(R,R)-(-)-6,6'-[(1,1'-Biphenyl-2,2'-diyl)]bis[4,8-di-t-butyl-1,2,10,11-tetramethyl]dibenzo[d,f][1,3,2]dioxaphosphepin,bisacetonitrileadduct,min.95%(R,R)-Kelliphite
CAS No.	729572-46-7
Molecular Formula	C58H68N2O4P2
Molecular Weight	919.11 g/mol
Synonyms	(R,R)-Kelliphite; (R,R)-(-)-Kelliphite; (R,R)-DTBM-Kelliphite; (R,R)-6,6'-Bis(2,4,6-tri-tert-butylphenyl)-3,3'-dimethyl-1,1'-biphenyl-2,2'-diyl bis(dibenzo[d,f][1,3,2]dioxaphosphepin) bis(acetonitrile) adduct; (R,R)-DTBM-SEGPHOS acetonitrile adduct (common misnomer); (R,R)-(-)-5,5'-Bis(di-3,5-di-tert-butyl-4-methoxyphenylphosphino)-4,4'-bi-1,3-benzodioxole acetonitrile adduct; Chiral phosphine ligand 729572-46-7.
EINECS	Contact for details

Quality Control

Our (R,R)-Kelliphite is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for chiral purity and assay, NMR for structural confirmation, and elemental analysis. A detailed Certificate of Analysis (COA) documenting identity, purity, and specific impurities is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry place. This material is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	Min. 95.0%
Chiral Purity (HPLC)	Min. 99.0% ee
Solvent Residue (GC)	Meet ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.