Description

S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 2-cyclobutylethanethioate is a sophisticated nucleotide-based prodrug compound designed for targeted therapeutic delivery. This molecule is engineered to enhance bioavailability and cellular uptake by combining a nucleoside monophosphate moiety with a lipophilic masking group. It is a critical advanced intermediate for research and development in the pharmaceutical sector, particularly for antiviral and anticancer applications. Its complex structure allows for precise metabolic activation within target cells.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel nucleotide analog prodrugs.
• Antiviral Drug Research: Investigated for the development of next-generation treatments for viral infections such as hepatitis and influenza.
• Oncology Research: Used in the development of targeted chemotherapeutic agents that require intracellular activation.
• Prodrug Development: A model compound for studying strategies to improve the membrane permeability and pharmacokinetics of polar nucleotide drugs.
• Biochemical Research: Employed in enzymatic studies and as a tool compound to investigate nucleoside transport and metabolism pathways.
• Preclinical Development: Supplied to biotechnology and pharmaceutical companies for in vitro and in vivo efficacy and safety studies.

Basic Information

Product Name	S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 2-cyclobutylethanethioate
CAS No.	6599-65-1
Molecular Formula	C30H49N8O16P3S
Molecular Weight	902.75 g/mol
Synonyms	2-Cyclobutylethanethioic Acid S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydro-2-furanyl]methoxy(hydroxy)phosphoryl]oxy(hydroxy)phosphoryl]oxy-2-hydroxy-3,3-dimethyl-1-oxobutyl]amino]-1-oxopropyl]amino]ethyl] Ester; Adenosine Monophosphate Prodrug Derivative; Nucleotide Prodrug Intermediate; GS-6620 Intermediate (related research compound); Cyclobutyl-AMP Prodrug; 6599-65-1; SATE Prodrug of Adenosine 5'-Monophosphate (analogous structure)
EINECS	Contact for details

Quality Control

Our S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 2-cyclobutylethanethioate is manufactured under GMP-like conditions suitable for pharmaceutical research. Each batch undergoes rigorous analytical testing including HPLC for purity and identity confirmation by NMR and Mass Spectrometry. Certificates of Analysis (COA) detailing purity, related substances, and residual solvents are provided to ensure traceability and compliance with your research and development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a desiccator to prevent degradation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Single Maximum Impurity (HPLC)	≤ 2.0%
Total Impurities (HPLC)	≤ 5.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.