Description

Oligomycin CAS NO 1404-19-9 is a potent, naturally occurring macrolide antibiotic complex produced by *Streptomyces* species, primarily known as a highly specific inhibitor of mitochondrial ATP synthase (F0F1 ATPase). This compound is an essential research tool in biochemistry and cell biology for studying oxidative phosphorylation, mitochondrial function, and cellular energy metabolism. It is critical for researchers and manufacturers in the life sciences sector, particularly those focused on metabolic research, drug discovery, and the development of assays for mitochondrial toxicity and bioenergetics profiling.

Application

• Mitochondrial Research: Used as a standard inhibitor to study the electron transport chain, oxidative phosphorylation, and ATP production mechanisms in cellular and isolated mitochondrial systems.
• Bioenergetics & Cell Metabolism Assays: A key component in Seahorse XF Analyzer and other extracellular flux assays to measure mitochondrial respiration and glycolytic function.
• Drug Discovery & Toxicology: Employed in screening platforms to identify compounds that affect mitochondrial function and to assess potential drug-induced mitochondrial toxicity.
• Apoptosis & Cancer Research: Investigated for its role in triggering apoptosis in cancer cells by disrupting cellular energy homeostasis.
• Biochemical Reagent: Serves as a critical standard and control in enzymatic studies of ATP synthase activity and inhibitor sensitivity.
• Antifungal Research: Studied for its inherent antifungal properties and as a lead compound for developing novel antifungal agents.

Basic Information

Product Name	Oligomycin
CAS No.	1404-19-9
Molecular Formula	C45H74O11 (for Oligomycin A)
Molecular Weight	791.1 g/mol (for Oligomycin A)
Synonyms	Oligomycin A; Oligomycin B; Oligomycin C; Oligomycin D; Oligomycin complex; 26-Methyl-5,14,20,22,24,28-hexamethyl-2,9-dioxatricyclo[23.3.1.14,8]nonacosa-4,6,8(28),11,13,15,17,19,24,26-decaene-3,10,21-trione; Antibiotic 1663; NSC 131233
EINECS	Contact for details

Quality Control

Our Oligomycin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications such as potency, purity, and solvent content to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. For long-term storage, desiccate to maintain stability. Allow the product to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Oligomycin A)
Total Oligomycins (A+B)	≥ 98%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Biological Activity	Conforms (IC50 for ATPase inhibition)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.