Description

Trichostatin A is a potent and selective hydroxamic acid-based inhibitor of histone deacetylases (HDACs). This compound is a critical research tool for studying epigenetic regulation, chromatin remodeling, and gene expression in cellular and molecular biology. It is essential for researchers and manufacturers in the fields of pharmaceutical development, oncology research, and epigenetics, where precise control of HDAC activity is required for drug discovery and mechanistic studies.

Application

• Epigenetics Research: A standard reagent for studying histone acetylation, chromatin structure, and gene silencing mechanisms.
• Oncology and Cancer Biology: Used to investigate the role of HDACs in cell proliferation, differentiation, and apoptosis, supporting anti-cancer drug discovery.
• Neuroscience Studies: Applied in research on neurodegenerative diseases and neuronal plasticity where epigenetic factors are implicated.
• Stem Cell Research: Utilized to modulate gene expression patterns and influence cell fate decisions during differentiation.
• Biochemical Assay Development: Serves as a positive control and potency standard in HDAC inhibitor screening assays and kit development.
• Inflammatory Disease Models: Employed to explore the epigenetic regulation of inflammatory pathways and immune responses.

Basic Information

Product Name	Trichostatin A
CAS No.	58880-19-6
Molecular Formula	C17H22N2O3
Molecular Weight	302.37 g/mol
Synonyms	TSA; [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide; (2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide; HDAC Inhibitor VIII; NSC 292309; Antibiotic TSA
EINECS	Contact for details

Quality Control

Our Trichostatin A is produced under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.