Description

Rauwolscine Hydrochloride is a high-purity, crystalline alkaloid salt derived from the Rauwolfia species. This compound is a selective α-2 adrenergic receptor antagonist, making it a critical reference standard and research chemical in neuropharmacology and drug discovery. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of analytical standards for studying receptor mechanisms, cardiovascular function, and metabolic pathways.

Application

• Pharmaceutical Reference Standard: Used for analytical method development, validation, and quality control in drug manufacturing and regulatory testing.
• Neuropharmacological Research: A key tool for investigating the role of α-2 adrenergic receptors in the central nervous system, including studies on anxiety, depression, and cognition.
• Cardiovascular Research: Employed in preclinical studies to examine vascular tone, blood pressure regulation, and sympathetic nervous system activity.
• Metabolic Studies: Applied in research exploring the influence of adrenergic systems on lipid metabolism, insulin sensitivity, and energy homeostasis.
• Biochemical Assay Development: Serves as a precise ligand in receptor binding assays and high-throughput screening (HTS) platforms.
• Academic & Clinical Research: Supports fundamental scientific investigations and potential therapeutic target identification in university and hospital laboratories.

Basic Information

Product Name	Rauwolscine Hydrochloride
CAS No.	6211-32-1
Molecular Formula	C21H26N2O3 · HCl
Molecular Weight	390.90 g/mol
Synonyms	α-Yohimbine Hydrochloride; Corynanthidine Hydrochloride; Raubasine Hydrochloride; 17α-Hydroxyyohimban-16α-carboxylic acid methyl ester hydrochloride; Isoyohimbine Hydrochloride; (16α,17α)-17-Hydroxyyohimban-16-carboxylic acid methyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our Rauwolscine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and stringent controls for residual solvents and heavy metals. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and development grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.