Description

6-Hydroxydopamine Hydrochloride is a potent and selective neurotoxin widely used in scientific research to create experimental models of neurodegenerative diseases. Its core value lies in its ability to selectively destroy catecholaminergic neurons, making it an indispensable tool for studying conditions like Parkinson's disease and sympathetic nervous system disorders. This compound is essential for researchers and institutions in the fields of neuroscience, pharmacology, and toxicology, where it is used to investigate neuronal death mechanisms and evaluate potential neuroprotective therapies.

Application

• Neurodegenerative Disease Modeling: Primary application for inducing selective lesions in dopaminergic and noradrenergic neurons to create experimental models of Parkinson's disease.
• Neuroscience Research: Critical tool for studying the mechanisms of neuronal death, axonal degeneration, and the role of oxidative stress in neural pathways.
• Pharmacological Screening: Used in preclinical studies to evaluate the efficacy of novel neuroprotective agents, antioxidants, and therapeutic compounds.
• Sympathetic Nervous System Studies: Employed to investigate the function and pathology of the peripheral sympathetic nervous system by chemical sympathectomy.
• Toxicology Assessments: Serves as a reference neurotoxin in studies examining the impact of environmental toxins on catecholamine systems.
• Cell Culture & In Vitro Studies: Applied in controlled in vitro environments to study specific cellular responses to neurotoxic insult.

Basic Information

Product Name	6-Hydroxydopamine Hydrochloride
CAS No.	28094-15-7
Molecular Formula	C8H12ClNO3
Molecular Weight	205.64 g/mol
Synonyms	6-OHDA HCl; 2,4,5-Trihydroxyphenethylamine Hydrochloride; 6-HydroxyDA Hydrochloride; Oxidopamine Hydrochloride; 6-Hydroxydopamine HCl; 6-Hydroxy Dopamine Hydrochloride; 2-(3,4,5-Trihydroxyphenyl)ethylamine Hydrochloride; NSC 169015
EINECS	Contact for details

Quality Control

Our 6-Hydroxydopamine Hydrochloride is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, and specifications can be provided to meet the stringent requirements of academic and pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere. Due to its hygroscopic and easily oxidized nature, the container must be kept sealed under dry conditions and opened only in a controlled environment to minimize exposure to moisture and air.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.