Description

Cytochalasin B is a potent, cell-permeable mycotoxin that acts as a specific inhibitor of actin polymerization, disrupting microfilament organization and function. This mechanism makes it an indispensable research tool for studying cytoskeletal dynamics, cell motility, and cytokinesis. It is primarily utilized by life science researchers and pharmaceutical developers in cell biology, cancer research, and toxicology studies.

Application

• Cytoskeletal Research: Fundamental tool for inhibiting actin filament elongation, used to study cell shape, motility, and the role of microfilaments in various cellular processes.
• Cell Biology Studies: Employed to investigate cytokinesis, phagocytosis, and intracellular transport mechanisms that depend on actin networks.
• Cancer Research: Used to examine the role of the actin cytoskeleton in tumor cell invasion, metastasis, and drug resistance.
• Toxicology: Serves as a model mycotoxin in studies investigating the effects of fungal metabolites on cellular health and function.
• Developmental Biology: Applied in research on embryogenesis and tissue morphogenesis where actin dynamics are critical.
• Pharmacology Screening: Used in assays to identify novel compounds that modulate actin dynamics or counteract cytoskeletal toxins.

Basic Information

Product Name	Cytochalasin B
CAS No.	14930-96-2
Molecular Formula	C₂₉H₃₇NO₅
Molecular Weight	479.61 g/mol
Synonyms	Phomin; NSC 209801; Cytochalasin B from *Zygosporium masonii*; [7-(Benzyloxy)-4a,5,6,7,8,8a,9,10-octahydro-5-methyl-6-oxo-4H-isochromen-4-yl]carbonyl]-L-phenylalanine; (3S,4aR,5S,6S,8aR,9R)-9-Benzyloxy-5-methyl-6-oxo-3-phenylacetyl-1,2,3,4,4a,5,6,8a-octahydro-7H-isochromene-4-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Cytochalasin B is produced and handled under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. The product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Solubility	Soluble in DMSO, ethanol; slightly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.