Description

(3S)-4-[[(1S)-1-[[(2S)-2-[[(2S)-2-acetamido-3-methyl-butanoyl]amino]-3-methyl-butanoyl]-[(3S,4S)-4-amino-3-hydroxy-6-methyl-heptanoyl]carbamoyl]ethyl]amino]-3-hydroxy-6-methyl-heptanoic acid is a complex, high-purity peptide derivative of significant interest in advanced pharmaceutical research and development. Its intricate stereochemistry and functional groups make it a valuable building block or intermediate for synthesizing novel therapeutic agents, particularly in the fields of oncology and metabolic disorders. This compound is essential for researchers and manufacturers requiring precise molecular scaffolds to explore new drug candidates and biological pathways. Its availability in consistent, high-quality grades supports critical work in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the multi-step synthesis of complex active pharmaceutical ingredients (APIs), especially peptide-based drugs.
• Medicinal Chemistry Research: Used as a precursor or template in drug discovery programs to develop new therapeutic molecules targeting specific enzymes or receptors.
• Bioconjugation: Its functional amino and carboxyl groups allow for site-specific conjugation in the development of antibody-drug conjugates (ADCs) or other targeted therapies.
• Process Development & Scale-up: Supports chemical process optimization and pilot-scale synthesis for new drug candidates before commercial manufacturing.
• Reference Standard: Can be utilized as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(3S)-4-[[(1S)-1-[[(2S)-2-[[(2S)-2-acetamido-3-methyl-butanoyl]amino]-3-methyl-butanoyl]-[(3S,4S)-4-amino-3-hydroxy-6-methyl-heptanoyl]carbamoyl]ethyl]amino]-3-hydroxy-6-methyl-heptanoic acid
CAS No.	56093-98-2
Molecular Formula	C31H56N6O8
Molecular Weight	640.81 g/mol
Synonyms	N-[(2S)-2-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-3-methylbutanoyl]-L-valyl-N-[(3S,4S)-4-amino-3-hydroxy-6-methylheptanoyl]-L-threoninamide; Cyclosporin G Metabolite; [Thr2,Leu5, D-Hiv8, Leu10]-Cyclosporin A; UNII-9P3H5WOG1C; (3S)-4-[[(1S)-1-[[(2S)-2-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-3-methylbutanoyl]-[(3S,4S)-4-amino-3-hydroxy-6-methylheptanoyl]carbamoyl]ethyl]amino]-3-hydroxy-6-methylheptanoic acid; 9P3H5WOG1C
EINECS	Contact for details

Quality Control

Our (3S)-4-[[(1S)-1-[[(2S)-2-[[(2S)-2-acetamido-3-methyl-butanoyl]amino]-3-methyl-butanoyl]-[(3S,4S)-4-amino-3-hydroxy-6-methyl-heptanoyl]carbamoyl]ethyl]amino]-3-hydroxy-6-methyl-heptanoic acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation by spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, related substances, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Optical Rotation	Specific range provided on COA
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.