Description

[(8S,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] acetate is a high-purity synthetic steroid derivative of significant interest in advanced pharmaceutical research and development. Its complex molecular structure, featuring key fluorinated and acetylated moieties, makes it a critical intermediate for the synthesis of potent glucocorticoid receptor agonists. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries who require reliable, high-quality building blocks for developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of potent topical and systemic corticosteroids, such as fluocinolone acetonide and related analogues.
• Active Pharmaceutical Ingredient (API) Development: Used in research and development for creating new steroid-based APIs targeting inflammatory and autoimmune conditions.
• Biochemical Research: Employed as a reference standard or probe in studies investigating glucocorticoid receptor binding, metabolism, and signaling pathways.
• Process Chemistry & Scale-Up: A vital compound for optimizing synthetic routes and scaling up production of steroid drugs in pilot plants and commercial manufacturing.
• Fine Chemical Synthesis: Utilized in custom synthesis and contract manufacturing for producing specialized steroid derivatives for clinical trials and niche markets.

Basic Information

Product Name	[(8S,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] acetate
CAS No.	5534-12-3
Molecular Formula	C₂₄H₃₁FO₆
Molecular Weight	434.50 g/mol
Synonyms	Fluocinolone Acetonide Acetate; 6α,9α-Difluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione Cyclic 16,17-Acetal with Acetone 21-Acetate; Fluocinolone Acetonide 21-Acetate; 9α-Fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione Cyclic 16,17-Acetal with Acetone 21-Acetate; 6α-Fluoro-16α-hydroxyprednisolone 16,17-acetonide 21-acetate; RS-2252; NSC-92338
EINECS	226-885-5

Quality Control

Our [(8S,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and R&D needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which could affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.