Description

(5Beta)-14-Hydroxy-3-Oxocard-20(22)-Enolide is a high-purity steroidal lactone compound, also known as Digitoxigenin, which serves as a crucial aglycone precursor in the synthesis of cardiac glycosides. This compound matters for its role as a key intermediate in the production of potent pharmaceuticals used to treat heart conditions, offering a reliable building block for complex organic synthesis. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions focused on cardiovascular drug development and steroid chemistry.

Application

• Pharmaceutical Intermediate: Primary building block for the synthesis of cardiac glycoside drugs like digoxin and digitoxin.
• Biochemical Research: Used as a reference standard and probe in studies of Na+/K+-ATPase enzyme inhibition and cardiac cell signaling pathways.
• Fine Chemical Synthesis: Serves as a chiral starting material for the preparation of more complex steroidal derivatives and novel bioactive molecules.
• Academic & Contract Research: Utilized in university and CRO laboratories for method development, teaching, and investigative pharmacology projects.
• Reference Material Production: Manufactured into certified reference standards (CRS) for quality control in pharmaceutical production.

Basic Information

Product Name	(5Beta)-14-Hydroxy-3-Oxocard-20(22)-Enolide
CAS No.	1102-88-1
Molecular Formula	C₂₃H₃₄O₄
Molecular Weight	374.51 g/mol
Synonyms	Digitoxigenin; 3β,14-Dihydroxy-5β-card-20(22)-enolide; Card-20(22)-enolide, 3,14-dihydroxy-, (3β,5β)-; 3β,14-Dihydroxy-5β-card-20(22)-enolide; (3β,5β)-3,14-Dihydroxycard-20(22)-enolide; 14-Hydroxy-3-oxocard-20(22)-enolide; NSC 75693; Aglycone of Digitoxin
EINECS	214-150-5

Quality Control

Our (5Beta)-14-Hydroxy-3-Oxocard-20(22)-Enolide is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all critical quality attributes to ensure compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and opened under inert atmosphere conditions for prolonged handling to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.