Description

Desmethyldoxepin is a key pharmaceutical intermediate and metabolite of the tricyclic antidepressant doxepin. This compound is of significant value for research and development in neuropharmacology and analytical chemistry. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories for drug metabolism studies, impurity profiling, and the synthesis of reference standards.

Application

• Pharmaceutical Intermediate: Critical for the synthesis and research of tricyclic antidepressant compounds and their derivatives.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical methods for quantifying doxepin and its metabolites in biological matrices (e.g., plasma, urine).
• Impurity Profiling: Essential for identifying and controlling process-related impurities and degradation products in doxepin active pharmaceutical ingredient (API) manufacturing, ensuring compliance with ICH guidelines.
• Pharmacological Research: Employed in preclinical and clinical studies to understand the pharmacokinetics, pharmacodynamics, and metabolic pathways of doxepin.
• Diagnostic Development: Potential use in developing diagnostic assays and kits for therapeutic drug monitoring (TDM).

Basic Information

Product Name	Desmethyldoxepin
CAS No.	1225-56-5
Molecular Formula	C18H19NO
Molecular Weight	265.35 g/mol
Synonyms	Nordoxepin; Desmethyldoxepine; N-Desmethyldoxepin; 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin; 1-Propanamine, 3-(6H-dibenz[b,e]oxepin-11-ylidene)-N-methyl-; Doxepin Metabolite
EINECS	214-949-5

Quality Control

Our Desmethyldoxepin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, assay, and impurity profile analysis via HPLC, to ensure high purity and consistency. Certificates of Analysis (COA) detailing all test results are provided to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.