Description

5-(n-Methyl-n-Propyl)Amiloride is a high-purity, research-grade chemical compound, a derivative of the well-known sodium channel blocker amiloride. This compound is valued for its specific pharmacological activity and is a critical intermediate in advanced pharmaceutical research and development. It is primarily utilized by research institutions, pharmaceutical companies, and biotechnology firms engaged in the study of ion transport mechanisms and the development of novel therapeutic agents.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the synthesis and study of novel amiloride analogs targeting epithelial sodium channels (ENaC).
• Biochemical Research: Used as a selective inhibitor in mechanistic studies of ion transport processes in cell biology and physiology.
• Academic Research: Employed in university and institutional labs for fundamental research into cardiovascular, renal, and pulmonary systems.
• Preclinical Studies: Acts as a tool compound in animal model studies to investigate the therapeutic potential of sodium channel modulation.
• Analytical Standard: Used as a certified reference material (CRM) for quality control and method validation in analytical laboratories.

Basic Information

Product Name	5-(n-Methyl-n-Propyl)Amiloride
CAS No.	1151-75-3
Molecular Formula	C12H19ClN6O
Molecular Weight	298.77 g/mol
Synonyms	5-(N-Methyl-N-propyl)amiloride; 5-(N-Methyl-N-propyl)amiloride hydrochloride; 3,5-Diamino-6-chloro-N-(methylpropyl)pyrazinecarboxamide; 5-(Methylpropyl)amiloride; Amiloride, 5-(N-methyl-N-propyl)-; N-amidino-3,5-diamino-6-chloro-N-(methylpropyl)pyrazinecarboxamide; 5-(N-Methyl-N-propyl)amiloride HCl
EINECS	Contact for details

Quality Control

Our 5-(n-Methyl-n-Propyl)Amiloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation via IR and NMR spectroscopy, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.