Description

Monocrotaline is a pyrrolizidine alkaloid of significant interest in biochemical and pharmaceutical research. This compound serves as a critical reference standard and a potent tool for studying specific biological mechanisms, particularly in the context of pulmonary and hepatic models. It is primarily utilized by research institutions, pharmaceutical development laboratories, and contract research organizations (CROs) engaged in toxicology, pharmacology, and natural product chemistry.

Application

• Biomedical Research Standard: Used as a high-purity analytical reference standard for method development and validation in HPLC, LC-MS, and other chromatographic techniques.
• Pharmacological Studies: Employed in preclinical research to investigate pulmonary hypertension and hepatotoxicity, serving as a model agent for inducing specific pathological conditions.
• Toxicology & Safety Assessment: A key compound in studies examining the mechanisms of pyrrolizidine alkaloid toxicity, crucial for food safety, herbal medicine, and environmental health research.
• Natural Product Chemistry: Acts as a representative marker compound for the analysis and quality control of plants containing pyrrolizidine alkaloids.
• Chemical Synthesis Intermediate: Utilized as a starting material or intermediate in the synthesis of more complex molecules for structure-activity relationship (SAR) studies.

Basic Information

Product Name	Monocrotaline
CAS No.	315-22-0
Molecular Formula	C₁₆H₂₃NO₆
Molecular Weight	325.36 g/mol
Synonyms	Monocrotaline; Crotaline; NSC-83616; Retronecine 3-(2-methyl-2,3-dihydroxybutanedioate) 8-ester; (13,14-Didehydro-12-hydroxy-13-methyl-7-oxo-4,6,8,12-tetrahydro-7H-pyrido[1',2':1,2]azepino[4,5-b]indol-5-yl)methyl 2-hydroxy-2-methyl-3-oxobutanoate
EINECS	206-254-4

Quality Control

Our Monocrotaline is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We support research compliance with traceable documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.