Description

2-Pyrazinecarboxamide, 3-[[4-[1-[[(3S)-1-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-3-pyrrolidinyl]methyl]-4-piperidinyl]phenyl]amino]-5-(1-piperidinyl)- is a sophisticated, high-purity small molecule building block designed for advanced pharmaceutical research and development. This compound is of significant interest for its potential role as a key intermediate or active pharmaceutical ingredient (API) in targeted therapeutic programs. It is primarily intended for use by research institutions, biotechnology firms, and pharmaceutical companies engaged in the discovery and synthesis of novel drug candidates, particularly in oncology and immunology.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of complex drug candidates.
• Proteolysis Targeting Chimera (PROTAC) Development: Used in the research and construction of heterobifunctional molecules designed for targeted protein degradation.
• Oncology Research: Investigated as a component in novel anti-cancer therapies, leveraging its structural features for targeted action.
• Chemical Biology Probes: Utilized in the development of molecular tools to study specific biological pathways and protein functions.
• Preclinical Drug Development: Employed in the synthesis of compounds for in vitro and in vivo pharmacological and toxicological studies.
• Process Chemistry & Scale-up: Supplied for route scouting, optimization, and initial scale-up activities from milligram to kilogram quantities.

Basic Information

Product Name	2-Pyrazinecarboxamide, 3-[[4-[1-[[(3S)-1-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-3-pyrrolidinyl]methyl]-4-piperidinyl]phenyl]amino]-5-(1-piperidinyl)-
CAS No.	2416131-46-7
Molecular Formula	C39H42N10O6
Molecular Weight	746.82 g/mol
Synonyms	3-((4-(1-(((S)-1-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)pyrrolidin-3-yl)methyl)piperidin-4-yl)phenyl)amino)-5-(piperidin-1-yl)pyrazine-2-carboxamide; PROTAC-related compound 2416131-46-7; (S)-Enantiomer of a cereblon-binding ligand derivative; Complex pyrazine-piperidine-pyrrolidine-isoindoline conjugate; Pharmaceutical intermediate 2416131-46-7.
EINECS	Contact for details

Quality Control

This high-value compound is manufactured under strict quality management systems to ensure batch-to-batch consistency and purity suitable for research applications. Identity and purity are confirmed via advanced analytical techniques including HPLC, LC-MS, and NMR. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. The compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (LC-MS)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Chiral Purity (Chiral HPLC)	≥ 99.0% ee

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.