Description

(6-{2-[3-(2-Benzyloxy-phenylcarbamoyl)-5-(4-fluoro-phenyl)-2-isopropyl-4-phenyl-d5-pyrrol-1-yl]-ethyl}-2,2-dimethyl-[1,3]-dioxane-4-yl)-acetic Acid, tert-Butyl Ester is a high-purity, deuterated pyrrole derivative designed for advanced research and development. This compound is a critical advanced pharmaceutical intermediate (API), offering significant value in the synthesis of novel drug candidates where isotopic labeling is required. It is primarily utilized by pharmaceutical R&D teams and contract research organizations (CROs) working in medicinal chemistry, metabolic studies, and the development of deuterated drugs.

Application

• Deuterated Drug Development: Serves as a key building block for synthesizing deuterium-labeled active pharmaceutical ingredients (APIs) to enhance metabolic stability and pharmacokinetic profiles.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel therapeutic agents targeting various disease pathways.
• Metabolic Pathway Tracing: Acts as a stable isotope-labeled standard in mass spectrometry for quantitative bioanalysis and metabolite identification studies.
• Process Chemistry & Scale-up: Employed in the development and optimization of scalable synthetic routes for complex, isotopically labeled molecules.
• Contract Research & Manufacturing: Supplied to CROs and CDMOs (Contract Development and Manufacturing Organizations) specializing in custom synthesis and early-phase clinical material production.
• Academic Research: Utilized in university and institutional labs for cutting-edge research in organic synthesis, catalysis, and chemical biology.

Basic Information

Product Name	(6-{2-[3-(2-Benzyloxy-phenylcarbamoyl)-5-(4-fluoro-phenyl)-2-isopropyl-4-phenyl-d5-pyrrol-1-yl]-ethyl}-2,2-dimethyl-[1,3]-dioxane-4-yl)-acetic Acid, tert-Butyl Ester
CAS No.	265989-41-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	tert-Butyl (6-{2-[3-(2-Benzyloxy-phenylcarbamoyl)-5-(4-fluoro-phenyl)-2-isopropyl-4-phenyl-d5-pyrrol-1-yl]-ethyl}-2,2-dimethyl-1,3-dioxan-4-yl)acetate; Deuterated Pyrrole Ester Intermediate; 265989-41-1; tert-Butyl 2-(6-{2-[3-[(2-benzyloxyphenyl)carbamoyl]-5-(4-fluorophenyl)-2-isopropyl-4-(phenyl-d5)-1H-pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxan-4-yl)acetate; Advanced Deuterated API Intermediate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for advanced intermediates. Each batch is characterized using advanced analytical techniques including HPLC, NMR (1H, 13C), and Mass Spectrometry to confirm identity, isotopic purity (deuterium content), and chemical purity. Certificates of Analysis (COA) detailing all specifications are available upon request. We adhere to a cGMP-compliant quality management system suitable for supporting pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect this moisture-sensitive material from humidity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Deuterium Content (MS)	≥ 95 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.