Description

(1R,2S)-2-(Benzoylamino)-1-[[[(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl]oxy]carbonyl]-2-phenylethyl ester L-glutamic acid homopolymer is a sophisticated, high-purity synthetic polymer derivative designed for advanced pharmaceutical research and development. This compound is critical for creating targeted drug delivery systems and enhancing the pharmacokinetic profiles of complex active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical manufacturers and advanced research institutions focused on oncology, targeted therapies, and novel formulation science.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex, high-value active pharmaceutical ingredients (APIs), particularly in oncology.
• Polymeric Prodrug Development: Used to create advanced prodrug systems where the active moiety is covalently linked to a biodegradable polymer backbone for controlled release.
• Targeted Drug Delivery: Enables the design of conjugates that improve drug solubility, stability, and targeted delivery to specific tissues or cells.
• Research & Development: Essential for academic and industrial R&D exploring new chemical entities (NCEs) and novel therapeutic modalities.
• Formulation Enhancement: Employed to modify the physical and chemical properties of drug compounds to improve bioavailability and patient compliance.

Basic Information

Product Name	(1R,2S)-2-(Benzoylamino)-1-[[[(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl]oxy]carbonyl]-2-phenylethyl ester L-glutamic acid homopolymer
CAS No.	263351-82-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Poly(L-glutamic acid) benzyl ester paclitaxel conjugate; PGA-PTX conjugate; Glutamic acid homopolymer, (1R,2S)-2-(benzoylamino)-1-[[[(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl]oxy]carbonyl]-2-phenylethyl ester; Paclitaxel polyglutamate conjugate; Taxol polymeric prodrug; 263351-82-2
EINECS	Contact for details

Quality Control

This high-purity pharmaceutical intermediate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and assay, NMR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets exacting R&D and cGMP-grade standards. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Moisture Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.