Description

S-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate is a sophisticated nucleotide-lipid conjugate, representing a high-value synthetic intermediate in advanced pharmaceutical research. This compound is critical for its role in the development of novel prodrugs and targeted delivery systems, particularly for antiviral and anticancer therapeutics. It is essential for R&D and process development teams in the pharmaceutical and biotechnology sectors seeking to enhance drug efficacy and specificity.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing nucleotide prodrugs, especially for antiviral applications (e.g., nucleoside phosphoramidate prodrugs).
• Lipid-Conjugate Research: Used in the development of lipophilic prodrugs to improve cellular uptake and bioavailability of nucleotide analogs.
• Targeted Drug Delivery: Serves as a precursor for constructing ligand-targeted therapeutic agents in oncology research.
• Bioconjugation Chemistry: Employed in creating stable thioether linkages for attaching active pharmaceutical ingredients to carriers or other functional molecules.
• Biochemical Research: Tool compound for studying enzyme kinetics and metabolic pathways involving modified nucleotides.
• Process Chemistry & Scale-up: Sourced by CDMOs and pharmaceutical companies for process development and cGMP manufacturing of clinical trial materials.

Basic Information

Item	Details
Product Name	S-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate
CAS No.	2152-91-2
Molecular Formula	C₃₃H₅₆N₇O₁₆P₃S
Molecular Weight	931.82 g/mol
Synonyms	Adenosine monophosphate prodrug intermediate; Nucleoside phosphoramidate lipid conjugate; (2R,3R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl (2R)-4-[[3-[[2-[[(3Z)-dodec-3-en-1-yl]sulfanyl]ethyl]amino]-3-oxopropyl]amino]-2-hydroxy-3,3-dimethyl-4-oxobutyl dihydrogen diphosphate; GS-7340 intermediate; Tenofovir alafenamide precursor derivative; Lipid-modified nucleoside phosphoramidate; S-Dodec-3-enethioate adenosine derivative
EINECS	Contact for details

Quality Control

Our S-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and chiral purity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and easily oxidized nature, store the product under an inert atmosphere (e.g., argon or nitrogen) at -20°C or below for long-term stability. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity	≥ 99.0% de
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.