Description

[1,1'-Biphenyl]-4-carboxylic acid, (3aR,4R,5R,6aS)-hexahydro-4-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]-2-oxo-2H-cyclopenta[b]furan-5-yl ester is a high-purity, complex organic ester with a defined stereochemistry, serving as a critical advanced intermediate in pharmaceutical synthesis. Its value lies in its precise molecular architecture, which is essential for constructing active pharmaceutical ingredients (APIs) with specific therapeutic effects. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical and fine chemical industries engaged in the development and production of novel drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of prostaglandin analogs and other potent bioactive molecules.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new therapeutic agents.
• Process Chemistry: Employed in route scouting and scale-up optimization for the commercial manufacturing of complex target molecules.
• Reference Standard: Utilized as an analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Item	Details
Product Name	[1,1'-Biphenyl]-4-carboxylic acid, (3aR,4R,5R,6aS)-hexahydro-4-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]-2-oxo-2H-cyclopenta[b]furan-5-yl ester
CAS No.	114488-91-4
Molecular Formula	C32H29F3O6
Molecular Weight	566.57 g/mol
Synonyms	Biphenyl-4-carboxylic acid, hexahydro-4-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]-2-oxo-2H-cyclopenta[b]furan-5-yl ester, (3aR,4R,5R,6aS)-; Latanoprost Impurity; Latanoprost Related Compound; Prostaglandin F2α Analogue Intermediate; (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-5-heptenoic Acid Phenyl Ester Derivative; UNII-6R7L2R4G8B; Bimatoprost Intermediate; Travoprost Related Compound
EINECS	Contact for details

Quality Control

Our [1,1'-Biphenyl]-4-carboxylic acid ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the stringent requirements for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) detailing identity, purity, and related substances are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. This compound is easily oxidized and should be handled under an inert atmosphere for long-term storage or after opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.