Description

Prostaglandin E1 CAS NO 745-65-3 is a potent, naturally occurring eicosanoid and a key member of the prostaglandin family, playing a crucial role as a vasodilator and platelet aggregation inhibitor. Its primary commercial value lies in its critical applications within pharmaceutical research, development, and manufacturing, particularly for cardiovascular and urological therapeutics. This high-purity compound is essential for researchers in drug discovery, formulation scientists, and manufacturers producing active pharmaceutical ingredients (APIs) for clinical use.

Application

• Pharmaceutical API Synthesis: A key intermediate in the manufacture of Alprostadil, a medication used to treat erectile dysfunction and to maintain patent ductus arteriosus in neonates.
• Cardiovascular Research: Used in preclinical and clinical studies investigating vasodilation, inhibition of platelet aggregation, and treatments for peripheral vascular diseases.
• Cell Culture & Biochemistry: Serves as a critical signaling molecule in cell-based assays and studies of inflammatory pathways, cyclic AMP regulation, and smooth muscle physiology.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for HPLC, GC, or MS method development and validation.
• Urological Applications: Research into its direct effects on smooth muscle tissue relevant to bladder and reproductive system disorders.
• Veterinary Medicine: Investigational use in animal health for similar vasoactive and reproductive applications.

Basic Information

Product Name	Prostaglandin E1
CAS No.	745-65-3
Molecular Formula	C20H34O5
Molecular Weight	354.48 g/mol
Synonyms	Alprostadil; PGE1; 11α,15α-Dihydroxy-9-oxoprost-13-en-1-oic acid; (11α,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid; Prostin VR; Prostavasin; Prostaglandin E1 (PGE1); (±)-Prostaglandin E1
EINECS	212-020-2

Quality Control

Our Prostaglandin E1 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, identification by IR and MS, and stringent control of related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with cGMP and relevant pharmacopeial guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0% w/w
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.