Description

Limaprost is a synthetic prostaglandin E1 (PGE1) analogue, a high-purity active pharmaceutical ingredient (API) with significant therapeutic value. Its primary commercial importance lies in its vasodilatory and antiplatelet aggregation properties, making it a critical component in pharmaceutical formulations. This product is essential for manufacturers in the pharmaceutical industry, particularly those developing treatments for peripheral vascular disorders and specific neurological conditions.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for improving peripheral circulation.
• Treatment of Peripheral Vascular Diseases: Formulated for drugs targeting conditions like thromboangiitis obliterans (Buerger's disease) and arteriosclerosis obliterans (ASO).
• Neurological Applications: Used in certain markets for the treatment of lumbar spinal canal stenosis, helping to improve blood flow and alleviate associated symptoms.
• Vasodilator Formulations: A key component in injectable or oral dosage forms designed to dilate blood vessels and inhibit platelet clumping.
• Clinical Research: Serves as a reference standard or investigational compound in cardiovascular and neurological research studies.
• GMP Manufacturing: Supplied for use in Good Manufacturing Practice (GMP) environments for the production of finished dosage forms.

Basic Information

Product Name	Limaprost
CAS No.	74397-12-9
Molecular Formula	C22H36O5
Molecular Weight	380.52 g/mol
Synonyms	Limaprost Alfadex; ONO 1206; Prostavasin; 11,15-Dihydroxy-9-oxo-5-cis-13-trans-prostadienoic acid; 17-Phenyl-18,19,20-trinorprostaglandin E1; Alfadex Limaprost; PGE1 Analogue
EINECS	Contact for details

Quality Control

Our Limaprost is manufactured under strict quality systems to meet the exacting standards of the pharmaceutical industry. Each batch undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, identification by spectroscopic methods (IR, NMR), and tests for residual solvents and heavy metals. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with relevant pharmacopoeial guidelines and customer-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.