Description

(5E,7E,14Z)-10-Chloro-12-Hydroxy-9-Oxoprosta-5,7,10,14-Tetren-1-Oic Acid Methyl Ester is a high-purity synthetic prostaglandin derivative, a key intermediate in advanced pharmaceutical research and development. This compound is valued for its specific stereochemistry and functional groups, which are critical for modulating biological pathways in medicinal chemistry. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for the synthesis of novel therapeutic agents and as a reference standard in analytical studies.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel prostaglandin-based drugs targeting inflammation, cardiovascular function, and ocular pressure.
• Biochemical Research: Used as a reference standard and probe in pharmacological studies to investigate receptor binding, enzyme activity, and cellular signaling pathways.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to develop new chemical entities with optimized therapeutic profiles.
• Analytical Standard: Employed in high-performance liquid chromatography (HPLC) and mass spectrometry (MS) for method development, validation, and quality control of related compounds.
• Process Development: Used in scaling up synthetic routes for the production of prostaglandin analogs under current Good Manufacturing Practice (cGMP) conditions.

Basic Information

Product Name	(5E,7E,14Z)-10-Chloro-12-Hydroxy-9-Oxoprosta-5,7,10,14-Tetren-1-Oic Acid Methyl Ester
CAS No.	100295-80-5
Molecular Formula	C21H27ClO5
Molecular Weight	394.89 g/mol
Synonyms	10-Chloro-12-hydroxy-9-oxoprosta-5,7,10,14-tetraen-1-oic acid methyl ester; Methyl 10-chloro-12-hydroxy-9-oxoprosta-5,7,10,14-tetraen-1-oate; 10-Chloro-12-hydroxy-9-oxo-PG methyl ester; Prostaglandin derivative 100295-80-5; 10-Cl-12-OH-9-oxo-PG methyl ester; (5E,7E,14Z)-10-Chloro-12-hydroxy-9-oxoprosta-5,7,10,14-tetraenoic acid methyl ester
EINECS	Contact for details

Quality Control

Our (5E,7E,14Z)-10-Chloro-12-Hydroxy-9-Oxoprosta-5,7,10,14-Tetren-1-Oic Acid Methyl Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. For long-term storage, desiccate to maintain stability. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.