Description

Butanoic acid, (1S,3S,5Z,7R,8E,11R,13E,15S,17R,21R,23R,25S)-1,11,21-trihydroxy-17-(1R)-1-hydroxyethyl-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo21.3.1.13,7.111,15nonacos-8-en-25-yl ester is a complex, high-purity macrolide derivative with significant biological activity. This compound is valued for its role as a critical advanced pharmaceutical intermediate in the synthesis of novel therapeutic agents. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of potent anti-infective and immunosuppressive drugs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of next-generation macrolide antibiotics and immunosuppressants.
• Biochemical Research: Used as a reference standard and probe compound in pharmacological and microbiological studies.
• Drug Discovery: Serves as a core scaffold for medicinal chemistry programs targeting bacterial infections and immune modulation.
• Process Development: Employed in scaling up and optimizing synthetic routes for complex active pharmaceutical ingredients (APIs).
• Analytical Standard: High-purity material for method development and validation in quality control laboratories.

Basic Information

Product Name	Butanoic acid, (1S,3S,5Z,7R,8E,11R,13E,15S,17R,21R,23R,25S)-1,11,21-trihydroxy-17-(1R)-1-hydroxyethyl-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo21.3.1.13,7.111,15nonacos-8-en-25-yl ester
CAS No.	107021-11-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	FK-506 Butanoate Derivative; Tacrolimus Related Compound; (1S,3S,5Z,7R,8E,11R,13E,15S,17R,21R,23R,25S)-25-Butanoyloxy-1,11,21-trihydroxy-17-(1-hydroxyethyl)-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-ene; Macrolide Ester Derivative; Advanced Tacrolimus Intermediate; Immunosuppressant Intermediate C
EINECS	Contact for details

Quality Control

Our high-purity pharmaceutical intermediate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with cGMP and ICH Q7 guidelines for active pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under dry, inert conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.