Description

Onx-0914 is a potent and selective small-molecule inhibitor of the immunoproteasome subunit LMP7 (β5i). This compound is a critical research tool for investigating proteasome function, immunology, and related disease pathways. It is primarily utilized by researchers and scientists in the fields of biochemistry, immunology, and oncology for target validation and mechanistic studies. The product is supplied under the identifier CAS NO 960374-59-8.

Application

• Biomedical Research: A key reagent for studying the role of the immunoproteasome in immune cell activation, cytokine production, and antigen presentation.
• Oncology Research: Used in in vitro and in vivo models to investigate its effects on cancer cell proliferation, apoptosis, and tumor microenvironment modulation.
• Autoimmune & Inflammatory Disease Research: Applied in studies targeting autoimmune conditions like rheumatoid arthritis, lupus, and multiple sclerosis where immunoproteasome activity is implicated.
• Mechanistic Pharmacology: Serves as a selective probe to dissect immunoproteasome-specific pathways versus constitutive proteasome functions.
• Drug Discovery & Development: Used as a reference compound or lead molecule in high-throughput screening and hit-to-lead optimization campaigns for novel therapeutics.

Basic Information

Product Name	Onx-0914
CAS No.	960374-59-8
Molecular Formula	C₂₀H₂₃N₃O₅
Molecular Weight	385.42 g/mol
Synonyms	PR-957; (S)-3-(4-Methoxy-3-(3-methylbutanamido)phenyl)-3-((S)-2-(2-morpholinoacetamido)-3-phenylpropanamido)propanoic acid; LMP7 Inhibitor; Immunoproteasome Inhibitor ONX-0914; β5i Inhibitor; ONX 0914; ONX0914
EINECS	Contact for details

Quality Control

Our Onx-0914 is produced under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC purity analysis, identity confirmation by spectroscopic methods, and residual solvent testing. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications for your records.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.