Description

Silvestrol Aglycone is a key chemical intermediate and reference standard derived from the natural product Silvestrol. This compound is of significant interest in pharmaceutical research and development due to its role as the core aglycone structure, which is essential for studying structure-activity relationships and developing novel therapeutic agents. It is primarily utilized by research institutions, pharmaceutical companies, and biotechnology firms engaged in oncology, virology, and medicinal chemistry programs.

Application

• Pharmaceutical Reference Standard: Used as a high-purity standard for analytical method development, validation, and quality control in drug discovery pipelines.
• Medicinal Chemistry Research: Serves as a critical intermediate or precursor for the synthesis of Silvestrol analogs and related compounds to explore new biological activities.
• Oncology Research: Employed in biochemical and cellular assays to investigate mechanisms of action related to protein synthesis inhibition and potential anti-cancer properties.
• Virology Studies: Utilized as a research tool in studies targeting viral replication, particularly for viruses like Ebola and SARS-CoV-2, where the parent compound has shown activity.
• Academic & Institutional Research: A vital compound for universities and research institutes conducting fundamental research in natural product chemistry and pharmacology.
• Biochemical Reagent: Acts as a specific inhibitor in pathway analysis to study eukaryotic translation initiation and the role of eIF4A.

Basic Information

Product Name	Silvestrol Aglycone
CAS No.	960365-65-5
Molecular Formula	C28H30O9
Molecular Weight	510.54 g/mol
Synonyms	(-)-Silvestrol Aglycone; 5,6-Dihydro-5,6-dihydroxy-2H,8H-benzo[1,2-b:5,4-b']dipyran-8-one, 10-[(1S,4aS,10aR)-1,4a,5,6,10,10a-hexahydro-1,4a-dihydroxy-1-(1-oxo-1,3-propadienyl)-6,10-dioxobenzo[g]isochromen-3-yl]-2,3-dimethoxy-, (5R,6S)-; Rocaglaol; Flavagline Derivative; Benzo[1,2-b:5,4-b']dipyran-8-one aglycone of Silvestrol
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch of Silvestrol Aglycone is characterized using advanced analytical techniques including HPLC, NMR, and MS to confirm identity, purity, and stability. Certificates of Analysis (COA) detailing all test results are available upon request. We adhere to cGMP guidelines for the manufacture of pharmaceutical intermediates to ensure traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under an inert atmosphere at -20°C. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.