Description

Plocabulin is a potent, synthetic small-molecule tubulin inhibitor with significant research and therapeutic potential. Its primary value lies in its unique mechanism of action, which disrupts microtubule dynamics and demonstrates promising activity against various cancer cell lines. This compound is essential for pharmaceutical R&D teams, medicinal chemists, and academic researchers focused on oncology drug discovery and the development of novel anti-mitotic agents. Plocabulin CAS NO 960210-99-5 represents a critical tool for advancing preclinical studies in targeted cancer therapy.

Application

• Oncology Research & Drug Discovery: A key reference standard and active pharmaceutical ingredient (API) in the development of next-generation anti-cancer therapeutics.
• Mechanistic Studies: Used in biochemical and cellular assays to study tubulin polymerization inhibition and its effects on cell cycle arrest and apoptosis.
• Preclinical Development: Serves as a lead compound for pharmacokinetic, pharmacodynamic, and toxicology evaluations in animal models.
• Medicinal Chemistry: Provides a core scaffold for structural-activity relationship (SAR) studies and the synthesis of novel analogs.
• Academic & Institutional Research: Utilized in university and research institute laboratories for fundamental cancer biology research.
• Biopharmaceutical Manufacturing: Sourced as a high-purity intermediate for the cGMP production of clinical trial materials.

Basic Information

Product Name	Plocabulin
CAS No.	960210-99-5
Molecular Formula	C31H38N4O6S
Molecular Weight	594.72 g/mol
Synonyms	PM060184; (1R,2S,3R,4S)-4-(7-{[(1S)-2-Hydroxy-1-methylethyl]amino}-5-[(phenylsulfonyl)amino]-1,3-benzothiazol-2-yl)-2,3-dihydroxy-N,N-dimethyl-2,3-O-(1-methylethylidene)cyclopentanecarboxamide; 2-Thiazolamine, N-(phenylsulfonyl)-, derivative; PM-060184; Plocabulin (PM060184); Tubulin inhibitor PM060184.
EINECS	Contact for details

Quality Control

Our Plocabulin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry guidelines to support our clients' regulatory and compliance needs in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities <2.0%
Water Content (KF)	<0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.