Description

6-Trifluoromethyl-3-Pyridinesulfonyl Chloride is a high-value, reactive chemical intermediate essential for modern synthetic chemistry. Its core value proposition lies in its role as a versatile sulfonylation reagent, enabling the efficient introduction of the 6-trifluoromethyl-3-pyridinesulfonyl moiety into target molecules. This compound is critically needed by R&D and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients, particularly where the trifluoromethylpyridine scaffold is desired for its beneficial effects on bioavailability and metabolic stability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the pyridine sulfonyl group enhances biological activity.
• Material Science Research: Serves as a precursor for functionalized ligands, monomers, or surface-modifying agents in specialty polymers and advanced materials.
• Chemical Biology & Proteomics: Employed as a reactive handle for labeling or modifying biomolecules in probe development and activity-based protein profiling (ABPP).
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Item	Detail
Product Name	6-Trifluoromethyl-3-Pyridinesulfonyl Chloride
CAS No.	959996-58-8
Molecular Formula	C7H3ClF3NO2S
Molecular Weight	245.62 g/mol
Synonyms	3-Pyridinesulfonyl chloride, 6-(trifluoromethyl)-; 6-(Trifluoromethyl)pyridine-3-sulfonyl chloride; 6-Trifluoromethylpyridine-3-sulfonyl chloride; 3-Pyridinesulfonyl chloride, 6-(trifluoromethyl)-; 959996-58-8; 6-Trifluoromethyl-3-pyridylsulfonyl chloride; 6-Trifluoromethyl-3-sulfonylchloridopyridine
EINECS	Contact for details

Quality Control

Our 6-Trifluoromethyl-3-Pyridinesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and moisture content analysis, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.