Description

Methanesulfonyl Chloride is a versatile and highly reactive sulfonyl chloride derivative, essential as a key building block in organic synthesis. Its primary value lies in its ability to act as a potent methanesulfonylation and chlorination reagent, enabling the introduction of the mesyl (Ms) protecting group and facilitating a wide range of nucleophilic substitution reactions. This compound is critically needed by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries for synthesizing active pharmaceutical ingredients (APIs), intermediates, and functional materials.

Application

• Pharmaceutical Intermediates: Key reagent for the synthesis of sulfonamides, sulfonate esters, and as a protecting group for alcohols and amines in multi-step API manufacturing.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides, where the mesyl group is incorporated to modify bioactivity and stability.
• Polymer & Material Science: Serves as a monomer or modifying agent in the creation of specialty polymers, ion-exchange resins, and surface-active agents.
• Organic Synthesis Reagent: Employed in classic reactions like the Mitsunobu reaction and for activating hydroxyl groups toward displacement in nucleophilic substitution.
• Dye & Pigment Manufacturing: Acts as an intermediate in the synthesis of sulfonated dyes and other colorants.
• Cross-coupling Reactions: Utilized in palladium-catalyzed cross-coupling processes to create complex carbon-carbon bonds.

Basic Information

Product Name	Methanesulfonyl Chloride
CAS No.	124-63-0
Molecular Formula	CH3ClO2S
Molecular Weight	114.55 g/mol
Synonyms	Mesyl Chloride; Methanesulphonyl Chloride; Methylsulfonyl Chloride; MSC; Methanesulfonic acid chloride; Methanesulfonic chloride; UN 3246
EINECS	204-706-2

Quality Control

Our Methanesulfonyl Chloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) for each lot, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases, amines, and oxidizing agents. Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under a dry inert atmosphere (e.g., nitrogen) to prevent hydrolysis. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	1.480 - 1.485 g/mL
Refractive Index (n20D)	1.451 - 1.453

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.