Description

Tosyl Chloride CAS NO 98-59-9 is a versatile and essential sulfonyl chloride reagent widely used in organic synthesis. Its primary value lies in its ability to act as a highly effective tosylating agent for alcohols and amines, facilitating the creation of sulfonate esters and sulfonamides, which are key intermediates and protecting groups. This compound is critically needed by research and development laboratories, pharmaceutical manufacturers, and fine chemical producers for applications ranging from drug discovery to polymer chemistry.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for introducing the tosyl (Ts) protecting group in multi-step synthesis of active pharmaceutical ingredients (APIs).
• Fine Chemical Production: Used in the manufacture of specialty chemicals, dyes, and photoinitiators.
• Polymer Chemistry: Serves as a monomer or modifier in the synthesis of specialty polymers and resins.
• Bioconjugation & Labeling: Employed to modify biomolecules like peptides and proteins for research and diagnostic applications.
• Catalyst & Ligand Preparation: Used to synthesize chiral sulfonamide ligands and organocatalysts.
• Analytical Chemistry: Acts as a derivatization agent for the analysis of alcohols and amines via chromatography.

Basic Information

Product Name	Tosyl Chloride
CAS No.	98-59-9
Molecular Formula	C7H7ClO2S
Molecular Weight	190.65 g/mol
Synonyms	p-Toluenesulfonyl chloride; 4-Toluenesulfonyl chloride; Tosyl chloride; TsCl; Toluene-4-sulfonyl chloride; p-Tosyl chloride; 4-Methylbenzenesulfonyl chloride; Toluenesulphonyl chloride
EINECS	202-684-8

Quality Control

Our Tosyl Chloride is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. We offer various grades, including standard technical and high-purity grades suitable for demanding synthetic applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, melting point, and impurity profile. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for critical pharmaceutical and fine chemical manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a temperature of 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Melting Point	67 - 69 °C
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.