Description

4-Methyl-3-Nitrobenzenesulfonyl Fluoride is a specialized aromatic sulfonyl fluoride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its unique reactivity as a sulfonylating agent, particularly useful for introducing the sulfonyl fluoride functional group, which is pivotal in modern click chemistry and bioconjugation applications. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of sulfonamide-based drugs and bioactive molecules.
• SuFEx Click Chemistry: Serves as a robust electrophile for Sulfur(VI) Fluoride Exchange reactions, enabling the rapid and reliable construction of complex molecules.
• Proteomics & Chemical Biology: Used in activity-based protein profiling (ABPP) and the development of covalent enzyme inhibitors.
• Agrochemical Synthesis: Intermediate for creating novel herbicides and fungicides with sulfonyl fluoride motifs.
• Polymer & Material Science: Functional monomer for modifying polymer surfaces and creating advanced materials with specific chemical handles.
• Organic Synthesis Reagent: Versatile reagent for introducing the 4-methyl-3-nitrobenzenesulfonyl protecting group or for further functionalization.

Basic Information

Product Name	4-Methyl-3-Nitrobenzenesulfonyl Fluoride
CAS No.	1535-47-3
Molecular Formula	C7H6FNO4S
Molecular Weight	219.19 g/mol
Synonyms	3-Nitro-4-methylbenzenesulfonyl fluoride; 4-Methyl-3-nitrobenzenesulfonyl fluoride; 2-Nitro-4-(fluorosulfonyl)toluene; 1-Fluorosulfonyl-2-methyl-5-nitrobenzene; 2-Methyl-5-nitrobenzenesulfonyl fluoride; NSC 403119; 4-Methyl-3-nitro-phenylsulfonyl fluoride
EINECS	Contact for details

Quality Control

Our 4-Methyl-3-Nitrobenzenesulfonyl Fluoride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.