Description

o-Toluenesulfonyl Chloride is a versatile and highly reactive organic intermediate, primarily used as a sulfonating and protecting agent in complex chemical syntheses. Its value lies in its ability to introduce the toluenesulfonyl (tosyl) group, a key step in the production of pharmaceuticals, agrochemicals, and specialty dyes. This compound is essential for R&D chemists and production facilities in the pharmaceutical, agrochemical, and fine chemical industries seeking reliable, high-purity building blocks for their processes.

Application

• Pharmaceutical Intermediate: A critical reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for creating sulfonamide drugs and as a protecting group for alcohols and amines.
• Agrochemical Synthesis: Used in the manufacture of herbicides, fungicides, and insecticides where the sulfonyl moiety is a key functional group.
• Dye and Pigment Production: Serves as an intermediate in the synthesis of sulfonated dyes and organic pigments, enhancing solubility and color properties.
• Polymer Chemistry: Employed as a modifier or cross-linking agent in the production of specialty polymers and resins.
• Chemical Research & Development: A fundamental tool in organic synthesis laboratories for method development and the creation of novel chemical entities.
• Fine Chemical Manufacturing: Used in the production of various fine chemicals, including flavors, fragrances, and photographic chemicals.

Basic Information

Product Name	o-Toluenesulfonyl Chloride
CAS No.	133-59-5
Molecular Formula	C7H7ClO2S
Molecular Weight	190.65 g/mol
Synonyms	2-Methylbenzenesulfonyl chloride; o-Tosyl chloride; 2-Toluenesulfonyl chloride; ortho-Toluenesulfonyl chloride; Benzenesulfonyl chloride, 2-methyl-; Toluene-2-sulfonyl chloride; o-TsCl
EINECS	205-117-8

Quality Control

Our o-Toluenesulfonyl Chloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) for every batch, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, ensuring the material meets the stringent requirements of advanced synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and reacts with water; containers must be kept tightly sealed to exclude moisture. Keep away from strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Melting Point	66 - 69 °C
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.