Description

Akt Inhibitor Iv CAS NO 959841-49-7 is a potent and selective small molecule inhibitor of the Akt (Protein Kinase B) signaling pathway. This compound is a critical research tool for investigating cellular processes related to proliferation, survival, and metabolism, with significant implications for oncology and metabolic disease research. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in preclinical drug discovery and target validation studies.

Application

• Biochemical Research: Used as a selective inhibitor to study the role of Akt isoforms (Akt1, Akt2, Akt3) in signal transduction pathways.
• Oncology Research: A key tool for in vitro and in vivo studies targeting cancers driven by PI3K/Akt/mTOR pathway dysregulation.
• Cell Biology Studies: Employed to investigate the effects of Akt inhibition on cell cycle progression, apoptosis, and glucose metabolism.
• Drug Discovery & Development: Serves as a reference compound or positive control in high-throughput screening (HTS) and lead optimization programs for kinase inhibitors.
• Metabolic Disease Research: Applied in studies exploring insulin signaling, glucose homeostasis, and related metabolic disorders.
• Academic & Institutional Research: Fundamental reagent for graduate and post-doctoral research projects focused on kinase biology and cellular signaling.

Basic Information

Product Name	Akt Inhibitor Iv
CAS No.	959841-49-7
Molecular Formula	C₂₀H₂₅N₅O₃
Molecular Weight	383.45 g/mol
Synonyms	8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one; Akt Inhibitor IV; Akti-1/2; Akt inhibitor 1/2; GSK690693 analog; CAS 959841-49-7
EINECS	Contact for details

Quality Control

Our Akt Inhibitor Iv is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including purity verification by HPLC and structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and other critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass Spec)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.