Description

5-Isobutylthiophene-2-Sulfonyl Chloride is a high-purity sulfonyl chloride derivative, a crucial building block in advanced organic synthesis. This compound matters for its role as a key electrophilic reagent, enabling the introduction of the sulfonamide functional group, which is fundamental in developing molecules with specific biological activities. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in creating novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of sulfonamide-based drug candidates, including protease inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and fungicides that require the sulfonamide moiety for efficacy.
• Material Science Research: Serves as a monomer or cross-linking agent in the creation of specialty polymers and functionalized surfaces.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes for studying enzyme function and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring high-purity sulfonylation reactions.

Basic Information

Product Name	5-Isobutylthiophene-2-Sulfonyl Chloride
CAS No.	958650-96-9
Molecular Formula	C8H11ClO2S2
Molecular Weight	238.75 g/mol
Synonyms	2-Thiophenesulfonyl chloride, 5-(2-methylpropyl)-; 5-(2-Methylpropyl)thiophene-2-sulfonyl chloride; 5-Isobutyl-2-thiophenesulfonyl chloride; 5-(Isobutyl)thiophene-2-sulfonyl chloride; 2-Thiophenesulfonyl chloride, 5-isobutyl-; Isobutylthiophene sulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 5-Isobutylthiophene-2-Sulfonyl Chloride is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong bases and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.