Description

Furin Inhibitor Ii Tfa CAS NO 958204-56-3 is a potent and selective synthetic peptide inhibitor of the proprotein convertase furin. This compound matters as a critical research tool for studying proteolytic processing pathways involved in numerous physiological and pathological processes, including viral entry, cancer progression, and bacterial toxin activation. It is primarily needed by researchers and developers in the fields of academic biochemistry, pharmaceutical R&D, and biotechnology for investigating disease mechanisms and validating furin as a therapeutic target.

Application

• Biochemical Research: Used as a specific inhibitor to study the role of furin in cellular protein processing and activation.
• Virology Studies: Applied in research to block furin-mediated cleavage of viral envelope glycoproteins, such as those from influenza, HIV, and SARS-CoV-2, to understand viral infectivity.
• Oncology Research: Utilized to investigate the involvement of furin in the activation of growth factors and metalloproteinases associated with tumor growth and metastasis.
• Bacterial Toxin Research: Employed to inhibit the activation of bacterial toxins like anthrax and Pseudomonas exotoxin A, which require furin cleavage for toxicity.
• Cell Signaling Pathway Analysis: Serves as a key reagent for dissecting signaling pathways that depend on furin-dependent maturation of receptors and ligands.
• Drug Discovery Screening: Acts as a reference compound or positive control in high-throughput assays designed to identify novel furin inhibitors.

Basic Information

Product Name	Furin Inhibitor Ii Tfa
CAS No.	958204-56-3
Molecular Formula	C41H58N12O10 • C2HF3O2
Molecular Weight	Contact for details
Synonyms	Furin Inhibitor II, TFA; Decanoyl-Arg-Val-Lys-Arg-CMK, TFA; Dec-RVKR-CMK, TFA; Furin Inhibitor II (Dec-RVKR-CMK), TFA; Furin Inhibitor II trifluoroacetate salt; Chloromethyl ketone inhibitor of furin; Proprotein Convertase Inhibitor; PCI; (2S)-5-[[(2S)-5-[[(2S)-5-[[(2S)-5-[(Aminoiminomethyl)amino]-1-[(2S)-1-[[(2S,3S)-1-chloro-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-2-[[(2S)-1-oxo-1-[[(2S,3S)-1-oxo-3-undecyloxolan-2-yl]amino]propan-2-yl]amino]-5-guanidinopentanoic acid; trifluoroacetic acid
EINECS	Contact for details

Quality Control

Our Furin Inhibitor Ii Tfa is produced under strict quality management protocols to ensure batch-to-batch consistency and high biological activity. Each lot undergoes rigorous analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and related substances is provided with every shipment to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion pattern
Purity (HPLC)	≥95%
Assay (HPLC)	≥98%
Water Content (KF)	≤2.0%
Solubility	Soluble in DMSO, slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.