Description

Isofagomine D-Tartrate CAS NO 957230-65-8 is a high-purity, enantiomerically pure salt form of the potent pharmacological chaperone, isofagomine. This compound is of significant interest for its role in modulating enzyme activity and stabilizing protein folding. It is primarily utilized by research institutions and pharmaceutical developers engaged in advanced therapeutic discovery, particularly for metabolic and neurodegenerative disorders.

Application

• Pharmacological Chaperone Research: A key tool for studying and developing treatments for lysosomal storage diseases like Gaucher's disease and Fabry disease by stabilizing mutant enzyme forms.
• Enzyme Inhibition Studies: Serves as a potent and selective inhibitor for glycosidase enzymes, facilitating biochemical pathway analysis and mechanism-of-action studies.
• Pharmaceutical Intermediate: Used in the synthesis and development of novel therapeutic agents targeting protein misfolding and aggregation.
• Biochemical Standard: Employed as a certified reference standard in analytical laboratories for quality control and method validation.
• Academic & Preclinical Research: Supports fundamental research in cell biology, neurobiology, and medicinal chemistry for investigating disease mechanisms.

Basic Information

Product Name	Isofagomine D-Tartrate
CAS No.	957230-65-8
Molecular Formula	C10H19NO8
Molecular Weight	281.26 g/mol
Synonyms	(1S,2R,3R,4S,5R)-1-(Hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol D-Tartrate; (1S,2R,3R,4S,5R)-1-(Hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol (2R,3R)-2,3-Dihydroxybutanedioate; Isofagomine (2R,3R)-2,3-Dihydroxybutanedioate Salt; AT3375; Plicera; AF102a D-Tartrate
EINECS	Contact for details

Quality Control

Our Isofagomine D-Tartrate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing including HPLC, NMR, and chiral purity analysis to ensure identity, potency, and purity meet exacting standards for research use. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). For long-term storage, consider desiccant and inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.