Description

4-(1-Amino-2-Methylpropan-2-Yl)Phenylboronic Acid, HCl is a specialized boronic acid derivative, a key building block in modern organic synthesis and pharmaceutical research. This compound matters for its role as a crucial intermediate in cross-coupling reactions, particularly Suzuki-Miyaura couplings, enabling the efficient construction of complex carbon-carbon bonds. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and other therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reagent: Serves as an essential organoboron partner for constructing biaryl and other complex aromatic structures in API development.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides requiring specific aromatic scaffolds.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and organic semiconductors, where precise molecular architecture is required.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the development of chemical probes and affinity ligands.
• Catalyst & Ligand Development: Utilized as a starting material for synthesizing novel chiral ligands and catalysts for asymmetric synthesis.

Basic Information

Product Name	4-(1-Amino-2-Methylpropan-2-Yl)Phenylboronic Acid, HCl
CAS No.	957120-45-5
Molecular Formula	C10H17BClNO2
Molecular Weight	229.51 g/mol
Synonyms	4-(1-Amino-2-methylpropan-2-yl)benzeneboronic acid hydrochloride; 2-Methyl-2-(4-boronophenyl)propan-1-amine hydrochloride; (4-(1-Amino-2-methylpropan-2-yl)phenyl)boronic acid HCl; B-[4-(1-Amino-2-methyl-2-propanyl)phenyl]boronic acid hydrochloride; 4-(2-Amino-2-methylpropyl)phenylboronic acid hydrochloride; 4-(1-Amino-2-methylpropyl)benzeneboronic acid HCl; 957120-45-5; Boronic acid, B-[4-(1-amino-2-methyl-2-propanyl)phenyl]-, hydrochloride
EINECS	Contact for details

Quality Control

Our 4-(1-Amino-2-Methylpropan-2-Yl)Phenylboronic Acid, HCl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure compliance with research and development grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (Titration)	95.0% - 105.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.