Description

2-Chloro-5-Methylphenylboronic Acid is a versatile and high-purity organoboron building block essential for modern synthetic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex biaryl motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides requiring specific chlorinated and methylated phenyl structures.
• Material Science Research: Serves as a precursor in the development of organic electronic materials, such as polymers for OLEDs and organic semiconductors.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for transition metal catalysis and organocatalysts.
• Chemical Biology Probes: Useful for creating tagged molecules and probes for studying biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: A critical reagent for custom synthesis houses serving the life sciences and specialty chemicals markets.

Basic Information

Product Name	2-Chloro-5-Methylphenylboronic Acid
CAS No.	193353-35-4
Molecular Formula	C7H8BClO2
Molecular Weight	170.40 g/mol
Synonyms	(2-Chloro-5-methylphenyl)boronic acid; 2-Chloro-5-methylbenzeneboronic acid; 5-Methyl-2-chlorophenylboronic acid; Boronic acid, B-(2-chloro-5-methylphenyl)-; 2-Chloro-5-methylphenyl-B(OH)2; 2-Chloro-p-tolylboronic acid; CAS 193353-35-4
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Methylphenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high chemical purity and consistent performance in cross-coupling reactions. Certificates of Analysis (COA) detailing batch-specific results are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and when dispensing to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.