Description

3-Chloro-2-Morpholino-4-Pyridineboronic Acid is a high-value boronic acid derivative and a crucial building block in modern synthetic chemistry. Its unique structure, combining a halogenated pyridine core with a morpholine substituent and a boronic acid functional group, makes it an indispensable reagent for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in cross-coupling reactions, such as the Suzuki-Miyaura reaction, to create novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, leveraging its halogen and boronic acid groups for structural diversification.
• Material Science Research: Serves as a precursor for synthesizing functionalized organic ligands and complex molecules used in organic electronic materials.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Catalyst & Ligand Development: Acts as a starting material for creating novel palladium catalyst ligands used in cross-coupling chemistry.
• Custom Synthesis & Contract Manufacturing: A critical raw material for custom synthesis organizations (CSOs) and CDMOs serving the life sciences sector.

Basic Information

Product Name	3-Chloro-2-Morpholino-4-Pyridineboronic Acid
CAS No.	957061-04-0
Molecular Formula	C9H12BClN2O3
Molecular Weight	242.47 g/mol
Synonyms	(3-Chloro-2-morpholin-4-ylpyridin-4-yl)boronic acid; 4-(3-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)morpholine (Pinacol ester precursor); 3-Chloro-2-morpholinopyridine-4-boronic acid; 2-Morpholino-3-chloro-4-pyridineboronic acid; 957061-04-0; B-(3-Chloro-2-morpholin-4-yl-4-pyridinyl)boronic acid
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-2-Morpholino-4-Pyridineboronic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. Certificates of Analysis (COA) detailing purity (typically by HPLC), identity (by 1H NMR and IR), and impurity profiles are available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a dry, cool, and well-ventilated place. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.