Description

4-Hydroxy-2-(Trifluoromethyl)Nicotinic Acid is a high-value, multi-functional heterocyclic building block distinguished by its trifluoromethyl and hydroxyl substituents. This compound is critical for researchers and manufacturers requiring precise molecular modifications to enhance the biological activity, metabolic stability, and physicochemical properties of target molecules. It is primarily sought after by the pharmaceutical and agrochemical industries for the synthesis of advanced intermediates in drug discovery and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and anti-inflammatory agents.
• Agrochemical Synthesis: Used in creating advanced herbicides and fungicides, where the trifluoromethyl group contributes to improved efficacy and environmental profile.
• Material Science Research: Serves as a precursor for functionalized ligands and monomers in the development of specialty polymers and advanced materials.
• Chemical Biology: Employed as a probe or building block in medicinal chemistry for structure-activity relationship (SAR) studies and hit-to-lead optimization.
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom synthesis services catering to R&D and pilot-scale production needs.

Basic Information

Product Name	4-Hydroxy-2-(Trifluoromethyl)Nicotinic Acid
CAS No.	956576-89-9
Molecular Formula	C7H4F3NO3
Molecular Weight	207.11 g/mol
Synonyms	2-(Trifluoromethyl)-4-hydroxynicotinic acid; 4-Hydroxy-2-(trifluoromethyl)pyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 4-hydroxy-2-(trifluoromethyl)-; 4-Hydroxy-2-trifluoromethylnicotinic acid; 956576-89-9; 4-Hydroxy-2-(trifluoromethyl)nicotinate
EINECS	Contact for details

Quality Control

Our 4-Hydroxy-2-(Trifluoromethyl)Nicotinic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for every shipment to ensure compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.