Description

5-Chloro-2-Fluoropyridine is a versatile and high-value halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both chlorine and fluorine substituents, enables precise molecular modifications essential for developing compounds with targeted properties. This intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules in drug discovery, particularly for candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands used in transition metal catalysis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and electronic materials that require specific halogenated aromatic components.
• Custom Synthesis and Contract Manufacturing: Supplied to fine chemical companies for the production of bespoke compounds and advanced intermediates under cGMP or ISO standards.

Basic Information

Product Name	5-Chloro-2-Fluoropyridine
CAS No.	1480-65-5
Molecular Formula	C5H3ClFN
Molecular Weight	131.53 g/mol
Synonyms	2-Fluoro-5-chloropyridine; 5-Chloro-2-fluoropyridine; 2-Fluoro-5-chloro-pyridine; 5-Chloro-2-fluoro-pyridine; 1480-65-5; Pyridine, 5-chloro-2-fluoro-; NSC 406921
EINECS	Contact for details

Quality Control

Our production of 5-Chloro-2-Fluoropyridine adheres to stringent quality management protocols. Every batch is analyzed using advanced techniques including GC, HPLC, and NMR to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, assay, and impurity profiles. Our quality system is designed to support applications requiring research-grade to cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.