Description

4-Methoxy-3-(trifluoromethoxy)benzenesulfonyl chloride is a high-purity, functionalized benzenesulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the unique combination of methoxy and trifluoromethoxy substituents, which impart specific electronic and steric properties to target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to introduce the sulfonyl chloride moiety for the creation of sulfonamides, sulfonate esters, and other valuable intermediates.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for creating novel sulfonamide-based drugs with potential therapeutic applications.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the sulfonyl group is a common pharmacophore.
• Material Science Research: Employed in the creation of specialized polymers, liquid crystals, and organic electronic materials due to its aromatic and electron-withdrawing characteristics.
• Chemical Biology & Proteomics: Acts as a reactive handle for bioconjugation and labeling strategies, modifying proteins or other biomolecules.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Item	Detail
Product Name	4-Methoxy-3-(Trifluoromethoxy)Benzenesulfonyl Chloride
CAS No.	956468-19-2
Molecular Formula	C8H6ClF3O4S
Molecular Weight	290.64 g/mol
Synonyms	1-Methoxy-2-(trifluoromethoxy)-4-(chlorosulfonyl)benzene; 4-Methoxy-α,α,α-trifluoro-3-(trifluoromethoxy)benzenesulfonyl chloride; 3-(Trifluoromethoxy)-4-methoxybenzenesulfonyl chloride; 4-Methoxy-3-trifluoromethoxybenzenesulfonyl chloride; 2-(Trifluoromethoxy)-4-methoxybenzenesulfonyl chloride; 1-Methoxy-2-(trifluoromethoxy)benzene-4-sulfonyl chloride
EINECS	Contact for details

Quality Control

Our 4-Methoxy-3-(trifluoromethoxy)benzenesulfonyl chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.