Description

Tcs Hdac6 20B is a potent and selective small molecule inhibitor of Histone Deacetylase 6 (HDAC6), a key enzyme involved in cellular processes such as protein degradation and cytoskeletal regulation. This compound is a critical research tool for investigating the role of HDAC6 in oncology, neurodegenerative diseases, and immunology. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in drug discovery and target validation studies.

Application

• Biomedical Research: A key reagent for studying HDAC6 biology, its role in aggresome formation, and its impact on microtubule dynamics.
• Drug Discovery & Development: Used as a reference standard and pharmacological tool in high-throughput screening (HTS) and lead optimization programs targeting HDAC6.
• Oncology Research: Investigated for its potential effects in cancer models, particularly in hematological malignancies and solid tumors where HDAC6 is implicated.
• Neurodegenerative Disease Studies: Applied in research models for diseases like Alzheimer's, Parkinson's, and Amyotrophic Lateral Sclerosis (ALS) to explore tauopathy and protein aggregation pathways.
• Immunology and Inflammation Research: Used to examine the modulation of immune cell function and inflammatory responses mediated by HDAC6 activity.
• Chemical Biology: Serves as a probe compound for understanding epigenetic mechanisms and developing isoform-selective HDAC inhibitors.

Basic Information

Item	Details
Product Name	Tcs Hdac6 20B
CAS No.	956154-63-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	TCS HDAC6 20B; HDAC6 Inhibitor, TCS; (2E)-N-Hydroxy-3-[1-[[4-[(2-hydroxyethyl)sulfamoyl]phenyl]amino]-1-oxopropan-2-yl]acrylamide; TCS HDAC6-20B; HDAC6 Inhibitor XX; Selective HDAC6 Inhibitor
EINECS	Contact for details

Quality Control

Our Tcs Hdac6 20B is produced under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (NMR, MS) and purity assessment by HPLC. A detailed Certificate of Analysis (COA) containing purity, potency, and analytical data is provided with every shipment to support your research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.