Description

(3,5-Difluoropyridin-4-Yl)Boronic Acid is a high-value organoboron building block essential for modern synthetic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone of pharmaceutical and agrochemical development. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex, fluorinated heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) containing difluoropyridine motifs, particularly in oncology and CNS drug candidates.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where the difluoropyridine group enhances biological activity and metabolic stability.
• Suzuki-Miyaura Cross-Coupling: A versatile reagent for palladium-catalyzed coupling with various aryl/heteroaryl halides to create biaryl and heterobiaryl structures.
• Material Science Research: Employed in the development of organic electronic materials, such as ligands for OLEDs and OFETs, where fluorination tunes electronic properties.
• Chemical Biology & Probe Development: Serves as a precursor for fluorinated molecular probes and tags used in bioimaging and diagnostic assays.
• Process Chemistry & Scale-up: Supports route scouting and optimization for the commercial manufacture of fluorinated fine chemicals.

Basic Information

Item	Details
Product Name	(3,5-Difluoropyridin-4-Yl)Boronic Acid
CAS No.	956003-87-5
Molecular Formula	C5H4BF2NO2
Molecular Weight	158.90 g/mol
Synonyms	4-Borono-3,5-difluoropyridine; (3,5-Difluoro-4-pyridinyl)boronic acid; 3,5-Difluoropyridine-4-boronic acid; 3,5-Difluoro-4-pyridylboronic acid; B-(3,5-Difluoropyridin-4-yl)boronic acid; 4-Pyridineboronic acid, 3,5-difluoro-; (3,5-Difluoropyridin-4-yl)boronic acid
EINECS	Contact for details

Quality Control

Our (3,5-Difluoropyridin-4-Yl)Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and reliable performance in sensitive cross-coupling reactions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive (hygroscopic) nature. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.