Description

(3R,4R)-Rel-3-Fluoro-4-Piperidinol Hydrochloride is a high-purity chiral piperidine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the precise stereochemistry and fluorine substitution, which are essential for modulating the biological activity and pharmacokinetic properties of target molecules. This compound is primarily needed by pharmaceutical R&D and process chemistry teams for the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disease research.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated drug candidates targeting neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the impact of fluorine and stereochemistry on drug-like properties.
• Process Development: Serves as a starting material or advanced intermediate in the scale-up and optimization of API manufacturing routes.
• Ligand and Catalyst Synthesis: Potential precursor for creating chiral ligands or organocatalysts used in asymmetric synthesis.
• Life Science Reagents: May be utilized in the development of biochemical probes and tool compounds for biological target validation.

Basic Information

Product Name	(3R,4R)-Rel-3-Fluoro-4-Piperidinol Hydrochloride
CAS No.	955028-84-9
Molecular Formula	C5H11ClFNO
Molecular Weight	155.60 g/mol
Synonyms	(3R,4R)-3-Fluoro-4-hydroxypiperidine hydrochloride; (3R,4R)-3-Fluoro-4-piperidinol hydrochloride; (3R,4R)-3-Fluoro-4-piperidinol HCl; (3R,4R)-3-Fluoro-4-hydroxy-piperidine HCl; (3R,4R)-3-Fluoro-4-piperidinol hydrochloride; rel-(3R,4R)-3-Fluoro-4-piperidinol hydrochloride; 3-Fluoro-4-piperidinol hydrochloride (3R,4R)-rel-; 4-Piperidinol, 3-fluoro-, hydrochloride, (3R,4R)-rel-
EINECS	Contact for details

Quality Control

Our (3R,4R)-Rel-3-Fluoro-4-Piperidinol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.