Description

2-Fluoro-4-(Trifluoromethoxy)Benzenesulfonyl Chloride is a high-value, multi-functional aromatic sulfonyl chloride derivative, serving as a critical synthetic intermediate in advanced chemical manufacturing. Its molecular structure, featuring both fluorine and trifluoromethoxy substituents, makes it an essential building block for introducing specific physicochemical properties into target molecules. This compound is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical sectors for the development of novel active ingredients, as well as by specialty chemical manufacturers for creating advanced materials and functional additives.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based drug candidates, particularly for central nervous system (CNS) and anti-infective therapeutics.
• Agrochemical Synthesis: Used in constructing novel herbicides, fungicides, and insecticides where the fluorine and trifluoromethoxy groups enhance biological activity and environmental stability.
• Material Science: Building block for creating specialty polymers, liquid crystals, and advanced electronic materials requiring specific dielectric properties.
• Chemical Research & Development: A versatile reagent for introducing the benzenesulfonyl moiety in complex organic synthesis and medicinal chemistry projects.
• Dye & Pigment Industry: Intermediate in the production of high-performance, light-fast dyes and functional pigments.

Basic Information

Product Name	2-Fluoro-4-(Trifluoromethoxy)Benzenesulfonyl Chloride
CAS No.	954388-19-3
Molecular Formula	C7H3ClF4O3S
Molecular Weight	278.61 g/mol
Synonyms	2-Fluoro-4-(trifluoromethoxy)benzene-1-sulfonyl chloride; 4-(Trifluoromethoxy)-2-fluorobenzenesulfonyl chloride; 1-(Chlorosulfonyl)-2-fluoro-4-(trifluoromethoxy)benzene; Benzenesulfonyl chloride, 2-fluoro-4-(trifluoromethoxy)-; 954388-19-3; 2-Fluoro-α,α,α-trifluoro-p-methoxybenzenesulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-4-(Trifluoromethoxy)Benzenesulfonyl Chloride is manufactured and tested under a strict quality management system. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles to ensure the material meets your precise research or production requirements. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates, ensuring traceability and reliability for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and reacts with strong acids/organic solvents; therefore, it must be kept under an inert atmosphere (e.g., nitrogen or argon) in a desiccated environment to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.