Description

5-(Trifluoromethyl)Thiophene-2-Sulfonyl Chloride is a high-purity, reactive sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the unique combination of the electron-withdrawing trifluoromethyl group and the versatile sulfonyl chloride functionality, enabling precise molecular modifications. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for sulfonamide-based drugs targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the thiophene-sulfonamide scaffold.
• Material Science: Building block for creating specialized polymers, liquid crystals, and organic electronic materials due to its aromatic and fluorinated structure.
• Chemical Research: A versatile reagent for introducing the 5-(trifluoromethyl)thiophene-2-sulfonyl moiety into complex molecules in medicinal and process chemistry.
• Dye and Pigment Industry: Intermediate in the production of specialized dyes and pigments where sulfur and fluorine groups impart specific properties.

Basic Information

Product Name	5-(Trifluoromethyl)Thiophene-2-Sulfonyl Chloride
CAS No.	954377-22-1
Molecular Formula	C5H2ClF3O2S2
Molecular Weight	250.64 g/mol
Synonyms	2-Thiophenesulfonyl chloride, 5-(trifluoromethyl)-; 5-(Trifluoromethyl)-2-thiophenesulfonyl chloride; 5-(Trifluoromethyl)thiophene-2-sulfonyl chloride; α,α,α-Trifluoro-2-thiophenesulfonyl chloride; 2-Thienylsulfonyl chloride, 5-(trifluoromethyl)-; 5-(Trifluoromethyl)thiophene-2-sulphonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 5-(Trifluoromethyl)Thiophene-2-Sulfonyl Chloride is manufactured and tested under strict quality management protocols to ensure consistency and reliability for your critical syntheses. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity (by HPLC/NMR), identity confirmation, and impurity profiles. Our quality systems are designed to support cGMP and ISO standards for pharmaceutical and fine chemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.